Penn State, which also has remaining games with Iowa, Indiana and Michigan State, hasn't won in Columbus in 30 years.
Quarterback Daryll Clark, who is from Youngstown, hopes to put an end to that losing streak against the Buckeyes.
"It's everything that you dream for when you come to a Big Ten school and you're from Ohio," he said. "And you're going down into the horseshoe and that's one of the most hostile places to play in.
"With everything working and the weapons we have and the coaches and all the other players we have we are very confident that we can go in there and weather the storm and actually get a win."