Penn State's Mens Tennis team (I know) beat Alabama, who is a top 25 team, then followed that up with a win over Boise State (ranked #35) at the Blue/Grey classic in Alabama.  Keep in mind that Tennis is a sport where top 100 is considered good.

For those of you who don't follow Tennis, Alabama was a big upset, and Boise a sold win. Penn State's (currently ranked in the mid-60's) tennis program was nowhere ten years ago and has really started to build itself up in to a nationally competitive team the past few years.  

http://www.collegian.psu.edu/archive/2008/03/13/mens_tennis_upsets_alabama.aspx

http://gopsusports.cstv.com/sports/m-tennis/recaps/031408aab.html