Disclaimer:  I haven't really scouted Purdue at all, much less Penn State, as Michigan couldn't face either team in their first game. 

Bischoff should be the starter today for Purdue.  I assume Macy for the Nittany Lions.  Macy has been fairly hot down the stretch, but doesn't generally go past 6 innings.  His last three starts are W@Minnesota (6 innings 0 runs), W vs Iowa (5 innings, 1 run), and L vs MSU (5.1 innings, 4 runs)  He didn't earn a starting job until after the Illinois series (6 starts now).  He never had an appearance against Purdue as he was the midweek starter right after the Purdue series (his first start of the season).

Bischoff was roughed up by PSU in his start.  He went 4 innnings, 6 hits, 5 runs (4 earned), on 4 walks and 5 Ks.  Nakata had 2 BBs and a single, Blackburn had 2 singles and a home run against him.  Other than that there were quite a few errors by Purdue, but Bischoff worked out of most of the trouble.

I almost like to say Penn State could win this one.  Bischoff has been near untouchable as of late though. 

Purdue 4 Penn State 3 (extra innings?)