Not sure how many people have seen this but ESPN has an ongoing feature on their website called "House of Pain," documenting the most painful losses in college football history.  The link is here:

ESPN House of Pain

I thought it would be interesting to get a list (and maybe eventually a poll) on Penn State's most painful losses.

To quote Beano Cook, "You never celebrate victory as deeply as you mourn defeat."

Now obviously there's a general correlation between the pain of a loss by what is at stake (like, say, a national championship), but there is also a correlation between the pain and the nature of the loss (like, say, blowing a lead late in a game).  I'm just curious what sticks in people's minds.

To get the ball rolling, here are the games I thought of, just in chronological order:

1/1/79 Sugar Bowl vs. Alabama

1/1/86 Orange Bowl vs Oklahoma

11/14/92 @ Notre Dame

11/6/99 home vs Minnesota

10/15/05 @ Michigan

11/17/07 @ Michigan State

11/8/08 @ Iowa